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For instance, there was an initial decrease followed by a dramatic increase in beta-endorphin

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Figure 4 Dihexa otoprotection is mediated by HGF/c-Met signaling We used the pharmacological inhibitor 6-AH to investigate if the observed protection conferred by Dihexa is actually mediated by HGF/c-Met signaling

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In contrast, adult immunization of this mouse strain, which is prone to develop diabetes, failed to protect, so timing was central to protection

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