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In a 12-week trial, GHK-Cu applied to thigh skin improved collagen production in 70% of treated women, compared to 50% for vitamin C cream and 40% for retinoic acid

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They often start with a higher dose, then get smaller doses based on how they do

61 This trend aligns with a multicenter review by Leclercq and Mathoulin, which suggested that at least 25 arthroscopic procedures annually and over five years experience are needed to minimize complication rates

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