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Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2

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For a man with testosterone of 300 ng/dL (low-normal), this could mean reaching 400-450 ng/dL or higher

They also promote macrophage polarization from the proinflammatory M1 phenotype to the anti-inflammatory M2 phenotype (Figure 2)