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NPY also plays a role in the neuroimmune crosstalk as evidenced by the fact that it is also produced by immune cells in response to activation and as a result modulates several immunological functions such as chemotaxis, T cell differentiation, antigen presenting cell function, leukocyte migration, neutrophil respiratory burst, and phagocytosis by binding to different Y receptor subtypes

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It was previously reported that homocysteinemia (Hcy) upregulated oxidative stress and ferroptosis by enhancing GPX4 methylation [158]

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