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To further validate the in vitro findings, an STZ-induced T2DM model in rats was established, and RYGB surgery was performed on T2DM rats, or T2DM rats were alternatively treated with GLP-1R agonist EX-4 and examined glucose metabolism- and lipid metabolism-related indicators were examined
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It supports proper nerve signals throughout the body, helps produce ATP (the bodys energy currency), and contributes to healthy blood pressure
b , The hydrogen-bond interaction network between residues associated with the ionic lock observed in the GLP-1R crystal structure 14,15,24
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