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These medications are also linked to changes in insulin response and blocking glucagon secretion, which plays a role in how the body manages blood sugar

The Lancet Diabetes & Endocrinology, 6 (4), 275-286

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The anionic nature of superoxide and the fact that it is mostly produced in the mitochondrial matrix determine that the bulk of antioxidant defenses to neutralize superoxide and other ROS reside in the matrix