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F.DhillonH
Severe glutathione depletion permits these intermediates to damage hepatocytes
Enzyme stability The cyclic disulfide bond structure makes it less likely to be degraded by proteases in adipose tissue, prolonging the action time
Almost all antioxidant genes involved in ferroptosis, such as NADPH regeneration, glutathione-regulated and lipid peroxidation, may be potential therapeutic targets
To try to overcome this, she teamed up with Walenskys lab, which had previously shown that stapling these small peptides can make them more stable and help them get into cells
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