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doi:10.1016/j.peptides.2025.171380
J.HwangA
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The single-cell transcriptomic analysis of GA patients revealed that the encoding gene, HIF-1A, is significantly upregulated in the monocytes of GA patients ( FAs can increase the de novo synthesis of HIF-1 at the translational level through fatty acid-binding protein 5 (FABP5) ( FAs may also increase uric acid levels by inhibiting the excretion process
The same set of experiments was conducted for GSSSG-pretreated HGF as a control and results indicated a nearly negligible preventive-effect on HGF nitration (Figure 2c), consistent with the earlier observation that GSSSG treatment barely enhanced HGF-c-met interaction before and after exposure to peroxynitrite (see again Figure 1e, bars 47 and bars 47 )
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