Theyre not doing anything illegal or unethicaltheyre practicing medicine based on available evidence, which overwhelmingly supports semaglutides effectiveness for weight loss regardless of diabetes status
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That comes from a different trial: the Phase 1 single-dose study in lean participants, where -hydroxybutyrate started below the assays detection floor and reached 708 mol/L at 4.5 mg by day 8 a large, dose-ordered rise in a lean cohort. The MASLD substudy, by contrast, found ketones moving only at 4 mg and above in a group with insulin resistance damping the readout
This condition runs in families which causes the ovaries to become enlarged and the formation of small cysts on the ovaries, as well as causing hormonal imbalances
doi: 10.1210/jc.2002-021518 14 ValassiESantosAYanevaMTothMStrasburgerCJChansonPet al