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The data indicated that H80 has significant GLP-1-mediated effects on the primary outcome in lean and prediabetic mice, showing a reduction in blood glucose levels at a dose of 4 g/kg by increasing plasma secretion of active GLP-1

In hypertension models, GLP-1 RAs exert beneficial effects through multiple mechanisms including vascular vasodilation, diuresis, decreased sympathetic activity in the central nervous system, and reduced blood pressure variability (BPV) [15]

IIH Several studies have explored the effect of GLP-1 RA use on IIH

Most evidence comes from rodent studies and user reports , not large clinical trials

The move also creates ripple effects across the industry