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Conversely, those with inadequate response (less than 5% weight loss after 12-16 weeks at therapeutic doses) should discontinue per FDA labeling

This points to the hypothesis that chronic hyperglycemia in diabetes, along with dysregulated central sensing of glucose concentrations in diabetics, may impair central transport of GLP-1 receptor agonist and explain the reduced efficacy for weight loss in type two diabetic patients. Geisler also discussed astrocytes

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