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By inhibiting osteoblast differentiation of VSMCs, GLP-1RAs can ameliorate phosphate-induced vascular calcification, which is mediated by the AMPK/mTOR pathway or AMPK/receptor activator of nuclear factor kappa B ligand (RANKL), as occurs in the osteoblast differentiation of VSMCs [128, 129]
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While these medication side effects often improve over time, they can significantly increase your fluid and electrolyte losses when they occur
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