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In the Phase 1 multiple-ascending dose (MAD) study, VK2735 achieved up to 8.2% mean weight loss at day 28 for the highest dose (100 mg)

If pancreatitis is suspected, semaglutide should be discontinued immediately and not restarted

For example, a patient on the 15 mg maintenance dose could step down to 10 mg, then 7.5 mg, then 5 mg, and finally 2.5 mg before complete discontinuation

Semaglutide also slows gastric emptyingthe rate at which food moves from the stomach into the small intestineparticularly during early treatment

This dual action amplifies effects on blood sugar control, appetite suppression, and weight loss