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These prescription-only medications work by mimicking natural hormones that regulate appetite and blood glucose levels, leading to reduced food intake and subsequent weight loss

Taking into account that SGLT-2i and GLP-1RA are recommended as therapeutic alternatives by many clinical guidelines, usually as second-line treatments after first-line metformin, new users of SGLT-2i appear to be a suitable active comparator group

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OHayre, M

Patients with specific genetic predispositions toward rapid muscle loss or lower baseline muscle mass may see greater benefit from creatine + semaglutide combination therapy