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Nuclear factor-B (NF-B) is the central signaling pathway regulating inflammation by mediating the expression of downstream proinflammatory cytokines, including TNF-, IL-6, and IL-1, which further impedes tissue recovery

doi: 10.3390/ijms22030992 95 Garca-GimnezJ

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The site includes Glu170 as well as candidate residues Gln143 (r 2 ) in helix 3, Arg152 (r 7 ) and Thr154-Pro156 in a loop preceding strand 3, and Gly167-Thr169 (r 46 ) in helix 4 (Figs 1c and 6a)