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The 2018 AHA/ACC cholesterol guideline recommends reassessing PCSK9 inhibitor therapy if patients report new symptoms, but emphasizes that the cardiovascular benefit in high-risk populations (LDL persistently above 70 mg/dL on maximally tolerated statin, with established ASCVD) typically outweighs side-effect risk [6]
Viana LV, Gross JL, Camargo JL, Zelmanovitz T, da Rocha EPC, Azevedo MJ
Study quality was generally moderate to high, though overall evidence certainty was rated low to very low due to limitations and imprecise estimates
At room temperature, degradation accelerated to 5-8% per month