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More serious adverse effects that have been observed or are theoretically possible based on the drug class include acute pancreatitis, gallbladder disease, and tachycardia

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However, it may also manifest as skin conditions such as systemic sclerosis, psoriasis, and rosacea (Parodi 2008)

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Tissue collection At 7 or 21 days after surgery, mice were euthanized by CO 2 asphyxiation, and the right hind limbs were fixed in freshly made 4% paraformaldehyde (Sigma-Aldrich) at 4 C for 24 h