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One possible explanation is the release of stored estrogen from fat cells as users lose weight

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In the 2022 semaglutide trial, participants blood pressure readings went back up to pretreatment levels after they stopped taking the medication

This information should be interpreted with a qualified healthcare provider and may support a more personalized conversation about baseline expectations, dosing strategy, and whether combination therapies (such as GLP-Squared dual compounds) align with your genetic profile