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Both the clinical and preclinical studies were targeted to obtain a comprehensive view
New evidence for P-gp-mediated export of amyloid- peptides in molecular, blood-brain barrier and neuronal models
153 Despite challenges such as compensatory upregulation of alternative transporters and feedback activation of resistance pathways, the transportome remains a tractable and druggable vulnerability
These risks are not DSIP-specific but are relevant to all injectable peptides used outside a clinical setting
The benefits build gradually, so consistency is key
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