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The HYL001 compound exerts its main mechanism of action through the down-regulation of GLS expression, thereby impeding glutamine metabolism
At the N-terminus, the His7 of Semaglutide forms a direct hydrogen bond with the side chain of Gln234 and a water mediated hydrogen bond with Tyr241 of the receptor
Indeed, it has been demonstrated that acetylation plays a key role in the control of CACT function that, together with the long-chain acyl-CoA dehydrogenase, contributes to -oxidation regulation
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