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In the Phase 2 trial published in the New England Journal of Medicine in 2023 (Jastreboff et al.), participants on the highest dose lost an average of about 24.2 percent of their body weight at 48 weeks, compared with roughly 2 percent on placebo
For example, oxidative stress is associated with loss of neurons
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Moreover, elevated cortisol levels impair neurogenesis in the hippocampus, a brain region involved in both depression and T2DM [74]
Back Dupr, J, Ross, SA, Watson, D, Brown, JC (1973) 'Stimulation of insulin secretion by gastric inhibitory polypeptide in man', Journal Clinical Endocrinology Metabolism , 37, 826-8
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