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Delta Sleep-Inducing Peptide (DSIP) is a nine-amino acid regulatory neuropeptide first identified in 1977 by Marcel Monnier and colleagues at the University of Basel, isolated from the cerebral venous blood of rabbits following low-frequency hypnogenic electrical stimulation of the intralaminar thalamic nuclei

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The Discovery Rabbit Thalamic Stimulation (1977) The original 1977 isolation by the Schoenenberger-Monnier group at Basel confirmed DSIP as a nonapeptide of MW 849 Da inducing primarily delta-sleep in rabbits, rats, mice, and humans with a more pronounced effect on REM sleep observed in cats establishing the species-dependent variation in DSIPs sleep-promoting profile that remains relevant to experimental design today