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Successful appeals require: A Letter of Medical Necessity from the prescribing provider that specifically addresses why tirzepatide is medically necessary for this patient, why alternative treatments are inadequate, and how the patient meets the payer clinical criteria

What they did: A Phase 1 clinical trial in Croatia in the 1990s2000s

Some protocols incorporate topical application to specific areas of concern alongside injectable administration for localized plus systemic benefits

As their baseline improves, some choose to transition into less frequent appointments

CJC-1295 was also banned by the FDA in 2024 because it carries a risk of increased heart rate and cardiac events (10)