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The mechanism for bronchospasm remains speculative but may involve NO-mediated bronchiolar smooth-muscle relaxation tipping into paradoxical constriction in susceptible individuals

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Nausea and Gastrointestinal Issues One of the most common side effects reported by tirzepatide users is nausea

Journal of Hepatology 50 , 11841191, doi: 10.1016/j.jhep.2009.01.030 (2009)