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Discovered for the first time in 1987, GLP-1 is an intestinal gut hormone that is secreted in response to food intake and potentiates the glucose-dependent insulin secretion from pancreatic -cells (Yang et al., 2022)

Curr Pharm Des 13(7):663669 Perry T, Lahiri DK, Sambamurti K, Chen D, Mattson MP, Egan JM, Greig NH (2003) Glucagon-like peptide-1 decreases endogenous amyloid- peptide (A) levels and protects hippocampal neurons from death induced by A and iron

58: 93150 Tosti A, Cadore de Farias D, Murrell DF

As of August 3, 2026, retatrutide remained investigational and was not approved by the FDA

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