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On average, patients on standard diabetes doses (0.5 mg or 1 mg weekly) can lose between 5 to 10 pounds over several months
So it was very important for our chain of thought and decision early on that we actually knew that GLP-1 had these separate effects and that they could work in the brain and have a separate effect on well-known pathways in the brain
doi:10.1016/0006-2952(91)90156-G Study: Declining glutathione levels with age increase oxidative damage and impact cellular health
Patients with severe gastrointestinal disease, including gastroparesis, may not tolerate the medication well
A 26-week clinical study comparing the effectiveness of liraglutide (1.8 mg once-daily) with exenatide (10 g twice-daily) indicates that patients treated with liraglutide had significantly greater reduction in HbA1c levels as well as significantly greater reduction in fasting plasma glucose levels as compared to patients treated with exenatide (Buse et al., 2009)
