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Tirzepatide Dual-action drug, targeting both glucose metabolism and appetite regulation

GLP-1 RAs are being studied [archived link] for use in many other medical conditions, including fatty liver disease, Parkinsons disease, and substance use disorders, among others

Identification of dual inhibitor of phosphodiesterase 1B/10A using structure-based drug design approach

PMID: 41972905 J EthnopharmacolLiquiritigenin alleviates inflammation and mitochondrial dysfunction in acute pancreatitis via ER-VDAC1 signaling

Thymosin beta 4 is also one of few compounds in this class with genuine randomised controlled human data, though in a topical ophthalmic formulation rather than a systemic one, RGN-259 eye drops having been evaluated in placebo-controlled Phase 2 and Phase 3 trials (Sosne et al., Cornea 2015 and Int J Mol Sci 2023)