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This delayed emptying prolongs the sensation of fullness (satiety) and contributes to weight loss, but it also means food remains in the stomach longer, potentially triggering nausea and discomfort
There is a dose relationship with risk for adverse events with ibuprofen and other NSAIDs, which are generally well tolerated at lower OTC doses
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Although much research has focused on mechanisms within the central nervous system to explain this pain suppression 8 , we hypothesize that additional mechanisms occurring in the peripheral nervous system are based on hormonal regulation during digestion
Hursel R, Viechtbauer W, Westerterp-Plantenga MS
