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In elderly individuals, chronically ill patients, or those with mitochondrial dysfunction, this conversion may be inefficient

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Moreover, short-term experiments may not be able to detect the impact of ANG II suppression on aldosterone levels, since aldosterone has slower rates of secretion and degradation than ANG II (66)

In particular of the common antipsychotics, thioridazine, perphenazine and pimozide are the strongest CYP2D6 inhibitors and therefore should not be prescribed alongside tamoxifen