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Research in humans is a bit less impressive Clinical trials in humans A 1981 double-blind study found that chronic insomniac patients found that subjects slept 59% more, shorter sleep latency, and higher sleep efficiency (Schneider 1981) A 1987 double-blind study did not find any statistically significant changes in sleep structure as measured by REM sleep, NREM sleep, or total sleep time (Debellis 1987) A 1992 double-blind study in 14 chronic insomnia patients found higher sleep efficiency and subjectively estimated tiredness decreased to similar levels of healthy subjects in 7 nights of injections (Schneider 1992) There are some limitations to these studies however

Signs of Vitamin B12 deficiency can include: Persistent fatigue or low energy levels Memory issues or difficulty concentrating Tingling or numbness in the hands and feet Pale or yellowed skin Mood changes, such as irritability or depression By replenishing your bodys B12 levels, injections can address these symptoms and help restore your vitality

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That work generated significant interest in the nootropic community, where Dihexa is now marketed as a cognitive enhancement compound