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Early studies have found that the brains of people with PD, AD, MS and mild cognitive impairment (MCI), exhibit high levels of oxidative damage, including mitochondrial dysfunction, DNA and protein damage, lipid peroxidation, and myelin injury [62, 63]
Compared to GLP- 1 receptor mono-agonists and GLP- 1 receptor/GIP receptor co-agonists, optimized triagonists improve energy expenditure and restore body weight in DIO mice
While this persistence rate is a marked improvement over the 10% observed for obesity-indicated GLP-1s, it still leaves 76% of potential demand unrealized
D., & Grossmann, M
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