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At the beginning of food intake, the activity of orexigenic signals is elevated while that of anorectic signals is suppressed

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Furthermore, astrocytes, the most abundant cells in the brain, serve as key regulators of brain glucose metabolism and neuronal functions [49]

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NAD+ as a signaling molecule: NAD+ and sirtuins in aging and disease. Nature Reviews Molecular Cell Biology, 13(7), 413-426

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