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This differential efficiency of reprogramming was also reflected in the transcriptomes of these cells, as evaluated by the enrichment of a reprogramming score composed of genes previously reported in MEFs that are poised to reprogram at 72 h of OSKM expression 48 (Extended Data Fig
Early metformin therapy (age 8-12 years) in girls with precocious pubarche to reduce hirsutism, androgen excess, and oligomenorrhea in adolescence
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