glutathione s transferase oxidative stress S-transferase: A versatile and dynamic enzyme Dual localization of glutathione S‐transferase

When free radical production exceeds your bodys ability to neutralize them, oxidative stress occurs, accelerating collagen breakdown and triggering excess pigmentation

& Bonar, S

Adv Neurol 45: 3542

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As mentioned above, RAS can also activate PI3K, triggering the PI3K/Akt/mTOR axis [111]