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Some of the most promising available treatments for the melasma are: elimination of causative factors, protection from UV radiations (with sunscreen application), and use of triple combination (hydroquinone, tretinoin, fluocinolone)

Roozbeh J, Sharifian M, Ghanizadeh A, Sahraian A, Sagheb MM, Shabani S, et al

Natural compounds such as baicalin, curcumin, epicatechin, and isoureguanidine alkaloids have shown promise in ICH models by upregulating GPX4 or SLC7A11 and enhancing cellular antioxidant defenses (210213)

And now it's like, well, I'm not finishing

Robert Glatter, MD, an emergency physician at Lenox Hill Hospital in New York City and assistant professor at Zucker School of Medicine, told Healthline that these findings support the idea that some patients may have partial biologic resistance to incretin-based therapies. He added that genetics explains only part of the treatment differences and that routine pharmacogenomic screening is not yet ready for widespread clinical use. The same article noted that this PAM research looked at bloodsugar control, not weight loss, and GLP1 drugs are typically prescribed at higher doses for obesity than for diabetes