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Patients with a history of depression, anxiety disorders, bipolar disorder, or previous suicidal thoughts warrant closer monitoring during GLP-1 treatment, as these pre-existing conditions represent the most significant risk factors for suicidal ideation

This serves to increase the solubility of these molecules for their excretion

This practice, while not uncommon, may carry different risk considerations, especially regarding potential vision side effects

For the spray, one dose twice daily with 30-60 seconds of sublingual holding is recommended

Mitch Biermann, an internal and obesity medicine specialist at San Diegos Scripps Clinic