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7.0 = dark red erythema with edema or vesicles, potentially extending beyond the test site

At present, over 80% of pancreatic cancer cases are in the unresectable tumor stage when diagnosed with extensive local invasion and metastases to distant organs (such as liver, lung, bone, etc.) ( Due to the high prevalence of prediabetic hyperglycemia and diabetes mellitus (DM) in pancreatic cancer patients (over 75% in high glucose status and 50% in diabetic status), a peripheral increase of insulin level and exogenous insulin injection can often be seen in PDA cases (Stolzenberg-Solomon et al., 2005

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Mechanically: if only pathway 1 is activated, initiation occurs without triggering