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We clustered 94% of the ATLAS participants into one of the five 1000 Genome superpopulation (African (AFR), admixed American (AMR), East Asian (EAS), European (EUR), Middle Eastern (MID), South Asian (SAS)) while the remaining individuals ancestry could not be ascertained
The most commonly reported injection site events included erythema (redness), induration (hardening), pain at the injection site, and itching
It can affect the liver microenvironment through GLP-1R in the immune system, adipose tissue, intestines, and the liver
Even if patients drink plenty of water, the livers biological cap for processing triglycerides is fixed, with the total amount of lipid that can be safely metabolized and excreted daily strictly limited to a few dozen grams
Abbreviations AE: Adverse event AgRP: Agouti-related peptide ALAT: Alanine aminotransferase Anti-CGRP mAbs: Monoclonal antibodies against calcitonin gene-related peptide AP: Area postrema BMI: Body mass index CART: Cocaine- and amphetamine-regulated transcript CGRP: Calcitonin gene-related peptide CSF: Cerebrospinal fluid ENS: Enteric nervous system FUP: Follow-up GCL: Ganglion cell layer GLP-1: Glucagon-like peptide-1 GLP-1-RA: Glucagon-like peptide-1 receptor agonist Hyp: Hypothalamus ICP: Intracranial pressure IIH: Idiopathic intracranial hypertension IIH-WOP: Idiopathic intracranial hypertension without papilledema MHD: Monthly headache days NPY: Neuropeptide Y NTS: Nucleus tractus solitarii OCT: Optical coherence tomography ONSD: Optic nerve sheath diameter POMS: Proopiomelanocortin pRNFL: Peripapillary retinal nerve fiber layer pwIIH: Patients with idiopathic intracranial hypertension SFO: Subfornical organ UCWM: Usual care weight management ULN: Upper limit of normal VIIH: Vienna Idiopathic Intracranial Hypertension References Mollan SP et al (2018) Idiopathic intracranial hypertension: consensus guidelines on management
