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Abbreviations PPI: Proton pump inhibitor GERD: Gastroesophageal reflux disease H + /K + ATPase pump: Hydrogen/potassium ATPase pump AGA: American Gastroenterological Association IBD: Inflammatory bowel disease BPAs: Best practice advice HCl: Hydrogen chloride AD: Alzheimer disease H2RA: H2 receptor antagonist APP: Amyloid precursor protein BACE 1: Beta-site amyloid precursor protein cleaving enzyme chAT: Human choline acetyltransferase Caco-2: Colorectal adenocarcinoma cells TRPM6/7: Transient receptor potential melastatin PTH: Parathyroid hormone SIBO: Small intestinal bacterial overgrowth LPS: Spontaneous bacterial peritonitis-SBP lipopolysaccharides CD: Crohns disease UC: Ulcerative colitis C