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Although precise hepatic anti-inflammatory mechanisms remain incompletely defined, proposed pathways include reduction of lipotoxicity-induced cellular stress, modulation of hepatic macrophage activity, and direct effects on inflammatory signaling cascades [26]
Patients with lower GLP1R sensitivity may benefit from tirzepatide (which targets dual pathways) instead of semaglutide alone
10.2337/dc14-2365 84
Empagliflozin as add-on to metformin in patients with type 2 diabetes: a 24-week, randomized, double-blind, placebo-controlled trial
W., James, L., Hahn, P
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