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Semaglutide and Tirzepatide) have become increasingly popular for the treatment of obesity and overweight
It is known as the master antioxidant in the body
"Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial." JAMA , 2021
REST directly binds to the promoter region of glutamate-cysteine ligase (GCLM), inhibits the synthesis of GSH through transcriptional inhibition of GCLM expression, and induces ferroptosis
Hence, further research is needed to elucidate the effects of GLP-1-RAs and GIP-GLP-1 co-agonists on metabolic adaptation in humans post MBS
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