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In animal models finerenone reduced the expression of genes encoding monocyte chemoattractant protein-1, matrix metalloproteinase-2 and plasminogen activator inhibitor-1 (related to tissue remodelling and fibrosis) in the kidney, and additionally demonstrated beneficial immunomodulatory effects [73]
Avoid skipping meals, as this may worsen nausea
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Dipeptidyl peptidase IV regulates proliferation of preglomerular vascular smooth muscle and mesangial cells
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