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Gastrointestinal adverse events - principally nausea, vomiting, diarrhea, and constipation - were more frequent in the semaglutide arm but were generally mild to moderate and occurred primarily during dose escalation [7]

Even though this effect may be mediated by the insulin receptor, experimental KO mice for the insulin receptor gene show a potent glucose lowering effect of IGF-1, indicative that the hypoglycaemic effect is also mediated, in part, by its own IGF-1R

Actin-binding effects extend the functional window further at the cellular level

c , Protein levels from cancer cell lines from DepMaps CCLE (Proteomics GGT1: P19440 (n = 339), GGT5: P36269 (n = 108), GGT6: Q6P531 (n = 45), GGT7: Q9UJ14 (n = 375))