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The redox inactivation of SAL1 promotes the transport of PAP from chloroplasts (and mitochondria) via PAPST transporters to the nucleus where it inhibits exoribonuclease-mediated RNA metabolism (Figure 2 and Supplementary Table 3)

Starting on a low dose helps reduce common side effects such as nausea, vomiting, or stomach upset

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Exemplary case from study group 4 (no-treatment control)

Many peptides remain in research chemical gray areas, not FDA-approved specifically for hair loss but available through compounding pharmacies or clinics for off-label use