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Histopathological findings revealed preservation of neural architecture, with reduced axonal degeneration, diminished neuronal loss, and limited formation of cystic cavities, suggesting an attenuation of secondary injury processes (12)

Advanced glycation end products (AGEs) exposure markedly impairs autophagic flux in renal TECs by activating the SMAD3/TFEB axis to suppress lysosome biogenesis and trigger lysosome depletion, leading to the accumulation of autophagosomes and SQSTM1/p62 ( Atg5 aggravates tubule injury and kidney damage, reflected as defective autophagy sensitized proximal TECs to ferroptosis (79)

This level of personalized support and guidance helps them stay motivated and accountable, which is essential for long-term success in achieving their weight loss goals.

Providers make these decisions based on weight-loss progress, metabolic markers, gastrointestinal tolerance, and comorbidities

Maintenance Create a long-term plan to protect results with sustainable nutrition, movement, and lifestyle habits