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These are different from systemic reactions, which sometimes include fever or headaches
Recent Prog Horm Res2004;59:267-85
Both NICE guidance (TA875) and the clinical trial evidence underpinning its approval emphasise that the medication must be used alongside a reduced-calorie diet and increased physical activity to achieve optimal outcomes
Annu Rev Nutr 1992
If symptoms worsen rather than improve after 4 hours, proceed to an emergency department
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