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Research has found that exposing renal tubular epithelial cells to various concentrations of CaOx crystal solution results in a significant increase in the expression of ferroptosis-related proteins such as p53, ACSL4, transferrin receptor (TRC), and TF as the concentration of CaOx crystals increases

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Such inhibition might diminish the inflammatory response, reducing cellular stress

doi: 10.1530/EC-23-0462 16 GuoR.SpyropoulosF.MichelT