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This feature would make them susceptible to transformation into a dopaminergic phenotype through TH synthesis

TLR4 can enhance the production of pro-inflammatory cytokines and chemokines, such as IL-6 and IL-17, by binding with exogenous ligands, like peptidoglycan, in FLS and peripheral blood mononuclear (PBMC) from RA patients, and trigger cartilage inflammation and degeneration (135)

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Signals are transmitted to the nucleus leading to the rapid and extensive reprogramming of gene expression patterns in host plant cells (Chisholm et al., 2012)

Despite decades of work, the precise receptor and mechanism are still not fully established