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Mechanistic tool in preclinical work: Used to explore lipid and glucose metabolism pathways in controlled models of energy balance
Researchers can pharmacologically dissect these pathways using LY294002 (PI3K inhibitor) or U0126 (MEK inhibitor) to determine which downstream arm mediates a specific IGF-1 LR3 effect in their experimental system
Understanding these differences helps you avoid wasting money on supplements that never deliver the results you expect
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