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n = 1394 receiving tirzepatide 5 mg, n = 1397 receiving tirzepatide 10 mg, n = 1408 receiving tirzepatide 15 mg and n = 2064 receiving placebo or active comparators) are shown in Table 1
These agents bind to GLP-1 receptors in the pancreas, enhancing glucose-dependent insulin secretion and suppressing glucagon release
What they discovered is that theres a fundamentally different approach available
Presented for research literature review only Kalkan KT et al
Rather than increasing CJC-1295 above its saturation dose, adding a second peptide that activates a completely different receptor (the ghrelin/GHS receptor) amplifies total GH release more efficiently
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